Dr. Peifeng Li served for 10 years as a medical researcher at the Max-Delbruck Center for Molecular Medicine in Germany. Currently, Dr. Li is a Professor of Medicine, and the Dean of the Institute for Translational Medicine, College of Medicine, Qingdao University. He is the Director, Key Laboratory of Nucleic Acid Biology in Cardiovascular Disease, Shandong, and the Director, International Research Centre for Non-coding RNAs and Translational Medicine, Qingdao.
Email: peifli@qdu.edu.cn
Awards and Honors (Selected)
1. Scholar of Taishan, Shandong, China
2. The leading innovative scientist in science and technology, Qingdao
3. Science and technology award, Second Prize. Qingdao Government
4. Yaomingkangde Biological Chemistry Award, China
5. Science and technology award, Third Prize. Beijing Government.
6. Medical science award, Second Prize, Chinese Medical Association
Professional Activities (Selected)
Grant Reviewer
2021 Grant Reviewer for France Science Foundation
2020 Grant Reviewer for The European Research Council
2018 Grant Reviewer for Austria Science Foundation
2011 Grant Reviewer for The Netherlands Organisation for Health Research and Development
2005-present Grant Reviewer for China National Science Foundation
Abstract Reviewer:
Reviewing abstracts submitted for the 18th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM)
Reviewing abstracts submitted for the 17th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM)
Membership:
2018-, Council member, Shandong Society for Cell Biology
2007-, American Heart Association
2007-, International Society for Heart Research
Editorial board: -Editorial board member, Clinical & Experimental Cardiology
-Editorial board member, Journal of Cardiology and Therapy
-Editorial board member, International Journal of Clinic Cardiology
-Editorial board member, Journal of Clinical Research
Associate editor: Molecular Biotechnology
Associate editor: Frontiers in Physiology-Redox Physiology
Publications (Selected)
Dr. Li has published papers in journals such as Molecular Cell, EMBO Journal, Nature Medicine, Nature Communications, Circulation, Circulation Research, and PNAS.
(1) Zhang L*, Ding H, Zhang Y, Wang Y, Zhu W, Li PF*. Circulating microRNAs: biogenesis and clinical significance in acute myocardial infarction. Front Physiol. 2020; 11: 1088.
(2) Sun T*, Wang K, Liu C, Wang Y, Wang J*, Li PF*. Identification of extrachromosomal linear microDNAs interacted with microRNAs in the cell nuclei. Cells. 2019; 8: 111.
(3) Lin Z#, Zhou Z#, Guo H, He Y, Pang X, Zhang X, Liu Y, Ao X, Li PF*, Wang J*. Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4. Cell Death & Disease. 2018; 9: 607.
(4) Sun T, Dong YH, Du W, Shi CY, Wang K, Tariq MA, Wang JX*, Li PF*. The role of microRNAs in myocardial infarction: from molecular mechanism to clinical application. International Journal of Molecular Sciences. 2017; 18: 745.
(5) Wang K#*, Long B#, Liu F#, Wang JX, Liu CY, Zhao B, Zhou LY, Sun T, Wang M, Yu T, Gong Y, Liu J, Dong YH, Li N, Li PF*. A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223. European Heart Journal. 2016; 37: 2602-2611.
(6) Wang JX#, Gao J#, Ding SL#, Wang K#, Jiao JQ, Wang Y, Sun T, Zhou LY, Long B, Zhang XJ, Li Q, Liu JP, Feng C, Liu J, Gong Y, Zhou ZX, Li PF*. Oxidative modification of miR-184 enables it to target Bcl-xL and Bcl-w. Molecular Cell. 2015; 59: 50-61.
(7) Li JC#, Li YZ#, Jiao JQ#, Wang JX, Li YR, Qin DN*, Li PF*. Mitofusin 1 is negatively regulated by microRNA 140 in cardiomyocyte apoptosis. Mol Cell Biol. 2014; 34: 1788-1799.
(8) Li M, Xia PY, Du Y, Liu SW, Huang GL, Chen J, Zhang HL, Hou N, Cheng X, Zhou LY, Li PF*, Yang X*, Fan ZS*. T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-Arrestin 2-mediated negative signaling. Journal of Biological Chemistry. 2014; 289: 17647-17657.
(9) Ding SL, Wang JX, Jiao JQ, Tu X, Wang Q, Liu F, Li Q, Gao J, Zhou QY, Gu DF*, Li PF*. A pre-mir-149 genetic variation affects mir-149 maturation and its ability to regulate puma in apoptosis. Journal of Biological Chemistry. 2013; 288: 26865-26877.
(10) Li Q, Zhou LY, Gao GF, Jiao JQ, Li PF*. Mitochondrial network in the heart. Protein & Cell. 2012; 3: 410-418.
(11) Ding SL#, Zhou LY#, Li PF*. MicroRNAs in cardiac hypertrophy: angels or devils. Wiley Interdisciplinary Reviews-RNA. 2011; 2: 124-134.
(12) Wang JX#, Jiao JQ#, Li Q, Long B, Wang K, Liu JP, Li YR, Li PF*. Mir-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1. Nature Medicine. 2011; 17: 71-78.
(13) Kalsotra A, Wang K, Li PF, Cooper TA*. MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development. Genes & Development. 2010; 24: 653-658.
(14) Wang JX, Li Q, Li PF*. Apoptosis repressor with caspase recruitment domain contributes to chemotherapy resistance by abolishing mitochondrial fission mediated by dynamin-related protein-1. Cancer Research. 2009; 69: 492-500.
(15) Lin ZQ#, Murtaza I#, Wang K, Jiao JQ, Gao J, Li PF*. miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106: 12103-12108.
(16) Tan WQ, Wang JX, Lin ZQ, Li YR, Lin Y, Li PF*. Novel cardiac apoptotic pathway the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Circulation. 2008; 118: 2268-2276.
(17) Li YZ#, Lu DY#, Tan WQ, Wang JX, Li PF*. p53 initiates apoptosis by transcriptionally targeting the antiapoptotic protein ARC. Mol Cell Biol. 2008; 28: 564-574.
(18) Li PF, Li JC, Muller EC, Otto A, Dietz R, von Harsdorf R*. Phosphorylation by protein kinase CK2: a signaling switch for the caspase-inhibiting protein ARC. Molecular Cell. 2002; 10: 247-258.
(19) Li PF, Dietz R, von Harsdorf R*. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2. EMBO Journal. 1999; 18: 6027-6036.
(20) von Harsdorf R*, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation. 1999; 99: 2934-2941.
(21) Li PF, Dietz R, von Harsdorf R*. Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells. Circulation. 1997; 96: 3602-3609.
Book Chapters
1. Vascular Biology (2nd Edition). Non-coding RNAs in vascular biology. 2014
2. Heart Failure. Cell death and heart failure. 2011
3. Advances in Free Radical Life Science. Multi-catalytic Proteinase. 1996
4. Advances in Free Radical Life Science. Oxidative modification of proteins. 1994
Research Interest
Molecular regulation of cardiovascular diseases and cancers. Focus on the role of non-coding RNAs in controlling mitochondrial network, apoptosis and necrosis.
