Yu Tao
Professor
yutao0112@qdu.edu.cn
Phone:86-10-82991791
Office: C429
Education
Ph.D., Sungkyunkwan University, 2009
M.S., Kangwon National University, 2007
B.S., Linyi University, 2002
Research Interests
1. Regulatory mechanism of epigenetic modification on cardiovascular disease;
2. The role and mechanism of noncoding RNA in the occurrence and development of cardiovascular diseases, including atherosclerosis, aortic dissection, abdominal aneurysm;
3. The study on the regulatory mechanism and therapeutic targets of chronic inflammation;
4. The delivery system researh of nucleic acid drugs;
5. Translation medicine research: Explore molecular markers for early diagnosis of vascular diseases and develop detection kit; Develop therapeutic targets of vascular diseases and relative drugs; Develop relative equipments in detection and therapeutics.
Selective Publications
(1) Tingyu Zong, Yanyan Yang, Xiaotong Lin, Hui Zhao, Meixin Liu, Yuanyuan Meng, Yong Li, Liang Zhao, Guozhang Tang, Kun Gong, Shaoyan Jiang, Zhibin Wang*, and Tao Yu*. 5 ’ -tiRNA-Cys-GCA regulates VSMC proliferation and phenotypic transition by targeting STAT4 in aortic dissection. Mol Ther Nucleic Acids. 2021 Jul 29;26:295-306.
(2) Yulin Zou, Yanyan Yang, Xiuxiu Fu, Xiangqin He, Meixin Liu, Tingyu Zong, Xiaolu Li, Lynn Htet Htet Aung, Zhibin Wang* and Tao Yu*. The regulatory roles of aminoacyl-tRNA synthetase in cardiovascular disease. Mol Ther Nucleic Acids. 2021 Jun 24;25:372-387.
(3) Li M, Yang Y, Wang Z, Zong T, Fu X, Aung LHH, Wang K, Wang JX, Tao Yu*.Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases. Angiogenesis. 2021 Feb;24(1):19-34.
(4) Li D, Yang Y, Wang S, He X, Liu M, Bai B, Tian C, Sun R, Tao Yu*, Chu X*. Role of acetylation in doxorubicin-induced cardiotoxicity. Redox Biol. 2021 Jul 31;46:102089. doi: 10.1016/j.redox.2021.102089.
(5) Li X, Yang Y, Wang Z, Jiang S, Meng Y, Song X, Zhao L, Zou L, Li M, Yu T*. Targeting non-coding RNAs in unstable atherosclerotic plaques: Mechanism, regulation, possibilities, and limitations. Int J Biol Sci. 2021 Aug 3;17(13):3413-3427.
(6) Xiaolu Li, Deqing Yin, Yanyan Yang, Chunhua Bi, Zhibin Wang, Guangren Ma, Xiuxiu Fu, Shengxiang Ji, Fachun Jiang, Tao Yu*. Eosinophil: A Nonnegligible Predictor In COVID-19 Re-positive Patientse-positive Patients, Front Immunol. 2021 Jul 29;12:690653.
(7) Zong T, Yang Y, Zhao H, Li L, Liu M, Fu X, Tang G, Zhou H, Aung LHH, Li P, Wang J, Wang Z, Tao Yu*. tsRNAs: Novel small molecules from cell function and regulatory mechanism to therapeutic targets. Cell Prolif. 2021 Mar;54(3):e12977.
(8) Xue Q, He N, Wang Z, Fu X, Aung LHH, Liu Y, Li M, Cho JY, Yang Y, Tao Yu*. Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis. J Ginseng Res. 2021 Jan;45(1):22-31.
(9) Fu X, Zong T, Yang P, Li L, Wang S, Wang Z, Li M, Li X, Zou Y, Zhang Y, Htet Aung LH, Yang Y, Tao Yu*. Nicotine: Regulatory roles and mechanisms in atherosclerosis progression. Food Chem Toxicol. 2021 May;151:112154.
(10) Fu X, He X, Yang Y, Jiang S, Wang S, Peng X, Tang G, Zong T, Li X, Zhang Y, Zou Y, Tao Yu*. Identification of transfer RNA-derived fragments and their potential roles in aortic dissection. Genomics. 2021 Jun 30;113(5):3039-3049.
(11) He X, Yang Y, Wang Q, Wang J, Li S, Li C, Zong T, Li X, Zhang Y, Zou Y, Tao Yu*. Expression Profiles and Potential Roles of Transfer RNA-derived Small RNAs in Atherosclerosis. J Cell Mol Med. 2021 Jul;25(14):7052-7065.
(12) Yang X, Yang Y, Guo J, Meng Y, Li M, Yang P, Liu X, Aung LHH, Tao Yu*, Li Y*. Targeting the epigenome in in-stent restenosis: from mechanisms to therapy. Mol Ther Nucleic Acids. 2021 Jan 26;23:1136-1160.
(13) Tian C, Yang Y, Bai B, Wang S, Liu M, Sun RC, Tao Yu*, Chu XM*. Potential of exosomes as diagnostic biomarkers and therapeutic carriers for doxorubicin-induced cardiotoxicity. Int J Biol Sci. 2021 Mar 27;17(5):1328-1338.
(14) Bai B, Yang Y, Wang Q, Li M, Tian C, Liu Y, Aung LHH, Li PF, Tao Yu*, Chu XM*.NLRP3 inflammasome in endothelial dysfunction. Cell Death Dis. 2020 Sep 18;11(9):776.
(15) Bai B, Yang Y, Ji S, Wang S, Peng X, Tian C, Sun RC, Tao Yu*, Chu XM*. MicroRNA-302c-3p inhibits endothelial cell pyroptosis via directly targeting NOD-, LRR- and pyrin domain-containing protein 3 in atherosclerosis. J Cell Mol Med. 2021 May;25(9):4373-4386.
(16) Cheng M, Yang Y, Xin H, Li M, Zong T, He X, Yu T*, Xin H. Non-coding RNAs in aortic
dissection: From biomarkers to therapeutic targets. J Cell Mol Med. 2020 Oct;24(20):11622-11637.
(17) He X, Lian Z, Yang Y, Wang Z, Fu X, Liu Y, Li M, Tian J, Tao Yu*, Xin H*. Long Non-coding RNA PEBP1P2 Suppresses Proliferative VSMCs Phenotypic Switching and Proliferation in Atherosclerosis. Mol Ther Nucleic Acids. 2020 Aug 19;22:84-98.
(18) Yu T*, Wang Z, Jie W, Fu X, Li B, Xu H, Liu Y, Li M, Kim E, Yang Y, Cho JY. The kinase inhibitor BX795 suppresses the inflammatory response via multiple kinases. Biochem Pharmacol. 2020 Apr;174:113797.
(19) Wang Q, Yang Y, Fu X, Wang Z, Liu Y, Li M, Zhang Y, Li Y, Li PF, Yu T*, Chu XM. Long noncoding RNA XXYLT1-AS2 regulates proliferation and adhesion by targeting the RNA binding protein FUS in HUVEC. Atherosclerosis. 2020 Apr;298:58-69.
(20) Liu Y, Yang Y, Wang Z, Fu X, Chu XM, Li Y, Wang Q, He X, Li M, Wang K, Wang JX, Li PF, Yu T*. Insights into the regulatory role of circRNA in angiogenesis and clinical implications. Atherosclerosis. 2020 Apr;298:14-26.
