The Center for Tumor Molecular Biology takes the research of new important tumor-related genes as the starting point to reveal the molecular mechanism and cellular signal pathway of the occurrence and development of malignant tumors. Then, it puts forward new targets and strategies for gene diagnosis and gene therapy to explore new ways to treat and prevent tumors. We mainly apply molecular biology, cell biology, genetic engineering model mice, and clinical specimens to study tumor basis and clinical transformations.

At present, our research focuses on the following directions:

1. Mitochondrial biology and tumor pathogenesis: mitochondria are the "energy factory" of cells. Abnormal mitochondrial function and structure are closely related to tumor occurrence, development, and metastasis. We focus on the regulation mechanism of mitochondrial dynamic structure (division and fusion) and clarify the role and molecular mechan

ism of related regulatory genes such as drp1, FIS1, and parkin in tumors.

2. Role and regulatory mechanism of noncoding RNA in tumorigenesis and development: There are various types of noncoding RNA in cells. More and more studies have found that these RNAs play important physiological and pathological functions. We aim to reveal the relationship between these noncoding RNAs, tumorigenesis, and development and explore their upstream regulatory mechanisms and downstream targets.

3. Cell death and tumor pathogenesis: Cell death is closely related to tumorigenesis and the formation of drug resistance. We focus on the molecular regulatory mechanisms of apoptosis, necrosis, and mitochondrial autophagy. Revealing the mechanism of tumor cell death is of positive significance for exploring tumor prevention and treatment.

4. Research and development of tumor transformation medicine and innovative drugs: This research direction is mainly engaged in the development of tumor gene diagnosis, gene therapies, and related genetic engineering products to transform the above theoretical research and apply it to clinic. Furthermore, we screen for new tumor markers and explore their application in clinical practice.

Director: Shan Peipei;

Tel.: 82991791;

Email: shanpeipei@qdu.edu.cn