Yanhan Dong, Ph. D
Deng Zhou Road 38, Qingdao 266021, China
Email: dongyanhande@163.com
Tel: 086-532-82991791
Education
2009-2014: Nanjing Agriculture University
Degree: Ph. D, in July, 2015
2005-2009: Nanjing Agriculture University
Degree: B. S. in July, 2009
Professional Faculty
2020-now Associate Professor, Institute for Translational Medicine,
Qingdao University, China
2014-2020 Assistant Professor, Institute for Translational Medicine,
Qingdao University, China
Research
2014-present Focus on non-coding RNAs in heart diseases; scRNA-seq and heart regeneration
2009-2014 Focus on effectors during the interaction between fungal Magnaporthe oryzae and rice through bioinformatic analyses, uncovering novel effectors and pathogenicity-related genes, revealing gene gain and lose dynamics in genome evolution.
Honours
1. The 100th excellent doctor degree dissertation in Jiangsu province, 2016
2. Second prize of Shandong Technological Invention Award, 2021, Second author
Selected Publications
(1) Yongmei Liu#, Yanhan Dong #, Xinjia He, Anjing Gong, Jinning Gao, Xiaodan Hao, Shuai Wang, Yuqiao Fan, Zibo Wang, Meng Li, Wenhua Xu*. piR-hsa-211106 Inhibits the Progression of Lung Adenocarcinoma Through Pyruvate Carboxylase and Enhances Chemotherapy Sensitivity. Front Oncol. 2021. Jun 23;11:651915.
(2) Yanhan Dong, Li Qian, Jiandong Liu*.
Molecular and cellular basis of embryonic cardiac chamber maturation. Semin Cell Dev Biol. 2021 Oct;118:144-149.
(3) Wang S#, Yanhan Dong #, Gong A, Kong H, Gao J, Hao X, Liu Y, Wang Z, Fan Y, Liu C*, Xu W*.
Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities. Int J Biol Sci. 2021 Jan 14;17(2):562-573.
(4) Kai Wang#, Yanhan Dong*#, Liu J, Qian L, Wang T, Gao X, Wang K, Zhou L*.
Effects of REDOX in Regulating and Treatment of Metabolic and Inflammatory Cardiovascular Diseases. Oxid Med Cell Longev. 2020 Nov 17;2020:5860356.
(5) Yanhan Dong*, Wenhua Xu, Cuiyun Liu, Peijun Liu, Peifeng Li*, Kun Wang*. Reactive oxygen species related noncoding RNAs as regulators of cardiovascular diseases, Int J Biol Sci. Int J Biol Sci. 2019 Jan 24;15(3):680-687.
(6) Yanhan Dong*, Sheng Xu, Jing Liu, Ponnusamy M, Yanfang Zhao, Yanhui Zhang, Qi Wang, Peifeng Li*, Kun Wang*. Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy, Int J Biol Sci. 2018 Jun 22;14(9):1133-1141.
(7) Yanhan Dong#, Cuiyun Liu#, Chao Chen,Yanfang Zhao, Kun Wang*, Peifeng Li*, Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases, Cell Mol Life Sci. 2018 Jan;75(2):291-300.
(8) Yanhan Dong, Ying Li, Zhongqiang Qi, Xiaobo Zheng, Zhengguang Zhang*, Genome plasticity in filamentous plant pathogens contributes to the emergence of novel effectors and their cellular processes in the host, Curr Genet, 2016, Feb;62(1):47-51
(9) Yanhan Dong, Qian Zhao, Xinyu Liu, Xiaofang Zhang, Zhongqiang Qi, Xiaobo Zheng, Zhengguang Zhang, Haifeng Zhang*, MoMyb1 is involved in stress response and is required for asexual development in the rice blast fungus Magnaporthe oryzae, BMC Microbiology, 2015, Feb 19;15:37
(10) Yanhan Dong, Ying Li, Miaomiao Zhao, Maofeng Jing, Xinyu Liu, Muxing Liu, Xianxian Guo, Xing Zhang, Yue Chen, Yongfeng Liu, Yanhong Liu, Wenwu Ye, Haifeng Zhang, Yuanchao Wang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang*, Global genome and transcriptome analyses of Magnaporthe oryzae epidemic isolate 98-06 uncover novel effectors and pathogenicity-related genes, revealing gene gain and lose dynamics in genome evolution, PLoS Pathog, 2015, Apr 2;11(4):e1004801.
(11) Liu CY, Zhang YH, Li RB, Zhou LY, An T, Zhang RC, Zhai M, Huang Y, Yan KW, Dong YH, Ponnusamy M, Shan C, Xu S, Wang Q, Zhang YH, Zhang J, Wang K. LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription. Nat Commun. 2018 Jan 2;9(1):29. doi: 10.1038/s41467-017-02280-y.
(12) Teng Sun, Yanhan Dong, Wei Du, Chunying Shi, Kun Wang, MA Tarip, Jianxun Wang, Peifeng Li*. The Role of MicroRNAs in Myocardial Infarction: From Molecular Mechanism to Clinical Application.. Int J Mol Sci. 2017 Mar 31;18(4).
(13) Zhongqiang Qi#, Muxing Liu#, Yanhan Dong, Qian Zhu, Lianwei Li, Bing Li, Jie Yang, Ying Li, Yanyan Ru, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang*, The syntaxin protein (MoSyn8) mediates intracellular trafficking to regulate conidiogenesis and pathogenicity of rice blast fungus, New Phytol, 2016 Mar;209(4):1655-67.
(14) Kun Wang*#, Fang Liu #, Cuiyun Liu #, An T, Jie Zhang, Luyu Zhou, Man Wang, Yanhan Dong, Na Li, Jinning Gao, Yanfang Zhao, Peifeng Li*. The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873. Cell Death and Differentiation, 2016 Aug;23(8):1394-405.
(15) Kun Wang *#, Bo Long #, Fang Liu #, Jianxun Wang, Cuiyun Liu, Bing Zhao, Luyu Zhou, Teng Sun, Man Wang, Tao Yu , Ying Gong, Jia Liu, Yanhan Dong, Na Li, Peifeng Li *, A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223, Eur Heart J, 2016 Sep 1;37(33):2602-11.
(16) Zhongqiang Qi, Muxing Liu, Yanhan Dong, Jie Yang, Haifeng Zhang, Xiaobo Zheng, Zhengguang Zhang*, Orotate phosphoribosyl transferase MoPyr5 is involved in uridine 5'-phosphate synthesis and pathogenesis of Magnaporthe oryzae, Appl Microbiol Biot, 2016 Apr;100(8):3655-66.
(17) Kun Wang, Luyu Zhou, Jianxun Wang, Yin Wang, Teng Sun, Bing Zhao, Yongjie Yang, Tao An, Bo Long, Na Li, Cuiyun Liu, Ying Gong, Jinning Gao, Yanhan Dong, Jian Zhang*, and Peifeng Li*, E2F1-dependent miR-421 regulates mitochondrial fragmentation and myocardial infarction by targeting Pink1, Nature Communications, 2015; 6: 7619.
(18) Yanfang Zhao, Murugavel Ponnusamy, Yanhan Dong, Lei Zhang, Kun Wang*, Peifeng Li*. Effects of miRNAs on myocardial apoptosis by modulating mitochondria related proteins. Clin Exp Pharmacol Physiol, 2016 Dec 23. doi: 10.1111/1440-1681.12720. [Epub ahead of print]
(19) Kun Wang*, Bo Long, Na Li, Ling Li, Cuiyun Liu, Yanhan Dong, Jinning Gao, Luyu Zhou, Chaoqun Wang, Peifeng Li*, MicroRNA-2861 regulates programmed necrosis in cardiomyocyte by impairing adenine nucleotide translocase 1 expression, Free Radic Biol Med, 2015, Nov 30;91:58-67.
(20) Yue Chen, Su Zhai, Yi Sun, Mengying Li, Yanhan Dong, Xiaoli Wang, Haifeng Zhang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang*, MoTup1 is required for growth, conidiogenesis and pathogenicity of Magnaporthe oryzae, Mol Plant Pathol, 2015 Oct;16(8):799-810.
(21) Haifeng Zhang, Hongyu Ma, Xin Xie, Jun Ji, Yanhan Dong, Yan Du, Wei Tang, Xiaobo Zheng，Ping Wang, Zhengguang Zhang*, Comparative proteomic analyses reveal that RGS proteins regulate amino acid metabolism of the rice blast fungus Magnaporthe oryzae, Proteomics, 2014, Nov;14(21-22):2508-22.
(22) Haifeng Zhang, Qian Zhao, Xianxian Guo, Min Guo, Zhongqiang Qi, Wei Tang, Yanhan Dong, Wenwu Ye, Xiaobo Zheng, Ping Wang, Zhengguang Zhang. Pleiotropic function of the putative Zinc-finger protein MoMsn2 in Magnaporthe oryzae, Mol Plant Microbe Interact, 2014, May;27(5):446-60.
(23) Min Guo, Yue Chen, Yan Du, Yanhan Dong, Wang Guo, Su Zhai, Haifeng Zhang, Suomeng Dong, Zhengguang Zhang*, Yuanchao Wang, Ping Wang, Xiaobo Zheng, The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and Is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae, PLoS Pathog, 2011, 7(2): e1001302.
Grants
2018-2020 Identification and characterization of MoNups effectors drived from a particular expression pattern in Magnaporthe oryzae
Natural Science Foundation of China, 31701733,
Role: PI. Total direct cost: RMB 260,000
2016-2019 Structural modulation of gut microbiota during high fat diet induced atherosclerosis and characterization of associated gut bacteria in mice
Shandong Provincial Natural Science Foundation, China, ZR2016CQ31
Role: PI. Total direct cost: RMB 130,000
2017-2019 The molecular mechanism of piRNA-8910 in the regulation of myocardial hypertrophy
Applied Basic Research Programs of Qingdao, China, 17-1-1-46-jch
Role: PI. Total direct cost: RMB 100,000
