Chang, Wen’guang
Education Background
2008.09-2010.06 Master in pharmacology trained by Norman Bethune Health Science Center of Jilin University
2010.09-2013.06 Doctor in pharmacology trained by Norman Bethune Health Science Center of Jilin University
Work Experience
2013.12-2015.12 Postdoctoral training in medical college of Manitoba University, Canada.
2016.09-present Assistant Professor in institution of translational medicine, Qingdao University
Research interest
Dr.Chang’s research interests cover basic research of insulin sensitivity, phospholipid metabolism and diabetes related cardiac complications.
Selected Publications
1. Wenguang Chang, Hongge Fa, Dandan Xiao, Jianxun Wang. MicroRNA-184 alleviates insulin resistance in cardiac myocytes and high fat diet-induced cardiac dysfunction in mice through the LPP3/DAG pathway. Mol Cell Endocrinol. (2020).
2. Wenguang Chang, Jianxun Wang*. Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus. Cells. (2019).
3. Wenguang Chang, Dandan Xiao, Xiang Ao, Mengyang Li, Tao Xu, Jianxun Wang*. Increased Dynamin-Related Protein 1-Dependent Mitochondrial Fission Contributes to High-Fat-Diet-Induced Cardiac Dysfunction and Insulin Resistance by Elevating Tafazzin in Mouse Hearts. Molecular Nutrition and Food Research. (2019).
4. Wenguang Chang, Li Chen, Grant M. Hatch*. Berberine treatment attenuates palmitate-induced insulin resistance through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes. Biochimica et Biophysica Acta-molecular and cell biology of lipids. (2016).
5. Hieu M. Nguyen, Edgard M. Mejia, Wenguang Chang, Ying Wang, Emily Watson, Ngoc On, Donald W. Miller and Grant M. Hatch. Cardiolipin regulates mitochondrial spare respiratory capacity and glucose transport into and across human brain cerebral microvascular endothelial cells. Journal of Neurochemisty. (2016).
6. Wenguang Chang, Ming Zhang, Jing Li, Zhaojie Meng, Shengnan Wei, Hongwei Du, Li Chen, Grant M. Hatch. Berberine improves insulin resistance in cardiomyocytes via activation of 5’-adenosine monophosphate-activated protein kinase. Metabolism. (2013).
