董妍涵,女,1987年出生,博士,副教授
2014年博士毕业于南京农业大学,同年进入威斯尼斯人8188cc工作。
博士期间主要从事微生物与寄主免疫系统互作机制的研究,并以第一作者身份在本领域顶级期刊PLoS Pathogens。目前共发表SCI论文25篇,其中第一作者SCI论文8篇;获得授权国家发明专利2项,新申请专利2项。主持国家自然科学基金、山东省和青岛市项目共计49万,并参与国家重点研究计划等多项课题。2016年入选江苏省百篇优秀博士毕业论文。
研究方向
1. 植物与病原微生物互作
2. 非编码RNA与心肌肥大
代表论文:(#第一作者,*通讯作者)
1. Yanhan Dong#, Ying Li, Miaomiao Zhao, Maofeng Jing, Xinyu Liu, Muxing Liu, Xianxian Guo, Xing Zhang, Yue Chen, Yongfeng Liu, Yanhong Liu, Wenwu Ye, Haifeng Zhang, Yuanchao Wang, Xiaobo Zheng, Ping Wang, Zhengguang Zhang*. Global genome and transcriptome analyses of Magnaporthe oryzae epidemic isolate 98-06 uncover novel effectors and pathogenicity-related genes, revealing gene gain and lose dynamics in genome evolution. PLoS Pathog. 2015 Apr 2;11(4):e1004801.
2. Dong Y#, Cheng H#, Liu Y, Xue M, Liang H*. Red yeast rice ameliorates high-fat diet-induced atherosclerosis in Apoe-/- mice in association with improved inflammation and altered gut microbiota composition. Food Funct. 2019 Jul 17;10(7):3880-3889.
3. Yanhan Dong#, Cuiyun Liu#, Chao Chen, Yanfang Zhao, Kun Wang*, Peifeng Li*, Role of noncoding RNAs in regulation of cardiac cell death and cardiovascular diseases,Cell Mol Life Sci. 2018 Jan;75(2):291-300.
4. Yanhan Dong*, Sheng Xu, Jing Liu, Ponnusamy M, Yanfang Zhao, Yanhui Zhang, Qi Wang, Peifeng Li*, Kun Wang*. Non-coding RNA-linked epigenetic regulation in cardiac hypertrophy, Int J Biol Sci. 2018 Jun 22;14(9):1133-1141.
5. Yanhan Dong*, Wenhua Xu, Cuiyun Liu, Peijun Liu, Peifeng Li*, Kun Wang*. Reactive oxygen species related noncoding RNAs as regulators of cardiovascular diseases, Int J Biol Sci. 2019 Jan 24;15(3):680-687.
6. Zhang L#, Dong Y#, Wang Y, Gao J, Lv J, Sun J, Li M, Wang M, Zhao Z, Wang J, Xu W. Long non-coding RNAs in ocular diseases: new and potential therapeutic targets. FEBS J. 2019 Jun;286(12):2261-2272.
7. Yanhan Dong#, Qian Zhao, Xinyu Liu, Xiaofang Zhang, Zhongqiang Qi, Xiaobo Zheng, Zhengguang Zhang, Haifeng Zhang*. MoMyb1 is involved in stress response and is required for asexual development in the rice blast fungus Magnaporthe oryzae. BMC Microbiology 2015 Dec;15(1):375.
8. Yanhan Dong#, Ying Li, Zhongqiang Qi, Xiaobo Zheng, Zhengguang Zhang*. Genome plasticity in filamentous plant pathogens contributes to the emergence of novel effectors and their cellular processes in the host. Curr Genet. 2015 Jul 31.
专利:
1. 张正光,董妍涵,王源超,郑小波,董莎萌. 稻瘟病菌无毒基因Avr-Pit 的分子标记检测方法及其引物. 专利申请号:ZL 2010 1 0506165.8(已授权)
2. 张正光,董妍涵,王源超,郑小波,董莎萌. 稻瘟病菌无毒基因Avr-Pit 分子标记. 专利申请号:ZL 2012 1 0242542.0(已授权)
主持科研项目:
1. 国家自然科学青年基金项目,31701733,稻瘟病菌中基于特定转录模式的MoNups效应分子作用机制研究,2018/01-2020/12,26.0万元,在研,主持
2. 山东省然科学青年基金项目,ZR2016CQ31,高脂饮食诱导的动脉粥样硬化对ApoE-/-小鼠肠道微生物组成的影响,2016/11-2019/06,13.0万元,在研,结题
3. 青岛市源头创新应用基础研究青年专项,17-1-1-46-jch,piRNA-8910调控心肌肥大的分子机制研究,2017/05-2019/05,10万元,在研,结题