卓越人才：单佩佩

单佩佩，女，1988年出生，博士，讲师。

2015年1月毕业于华东师范大学生物医学专业，获得博士学位，同年7月进入上海交通大学附属第一人民医院临床转化研究院任助理研究员，2017年进入威斯尼斯人8188cc工作，2017年入选威斯尼斯人8188cc青年卓越人才计划。从2009年开始从事与肿瘤、脂肪和能量代谢异常及常见临床类疾病相关的蛋白质功能及其调控机制研究，为相关疾病的预防、诊断和治疗提供新的思路和理论依据。目前主持国家自然科学基金青年项目一项，参与国家自然科学基金面上项目3项，共发表SCI论文7篇，其中以第一作者（含共同第一作者）在Nature Communication（影响因子12.353）、Current Biology（影响因子9.251）等杂志发表SCI论文3篇，累计影响因子33.183。

研究方向：

1. 肿瘤发生机制研究；

2. 肿瘤耐药性分子机制研究；

3. 蛋白质翻译后修饰（乙酰化、磷酸化、泛素化、Sumo化）及相关疾病关系研究；

4. 肿瘤发生过程中核酸甲基化修饰谱与肿瘤分子生物学；

5. 治疗肿瘤新型小分子药物筛选及其作用机制研究。

代表论文：(#第一作者，*通讯作者)

1. Peipei Shan^#, Guangjian Fan^#, Lianhui Sun^#, Jinqin Liu, Weifang Wang, Chen Hu, Xiaohong Zhang, Qiwei Zhai, Xiaoyu Song, Liu Cao, Yongping Cui, Shengping Zhang^*, Chuangui Wang^*, SIRT1 Functions as a Negative Regulator of Eukaryotic Poly(A)RNA Transport. Current Biology (IF: 9.251), 2017. 27(15): p. 2271-2284.

2. Lianhui Sun^#, Guangjian Fan^#, Peipei Shan^#, Xiaoying Qiu, Shuxian Dong, Lujian Liao, Chunlei Yu, Tingting Wang, Xiaoyang Gu, Qian Li, Xiaoyu Song, Liu Cao, Xiaotao Li, Yongping Cui, Shengping Zhang^*, Chuangui Wang^*, Regulation of energy homeostasis by the ubiquitin-independent REGgamma proteasome-independent REGγ proteasome. Nature Communications (IF:12.353), 2016 Aug 11;7:12497.

3. Guangjian Fan^#, Lianhui Sun^#, Peipei Shan^#, Xianying Zhang, Jinliang Huan, Xiaohong Zhang, Dali Li1,Tingting Wang, Tingting Wei, Xiaohong Zhang, Xiaoyang Gu, Liangfang Yao, Yang Xuan, Zhaoyuan Hou, Yongping Cui6, Liu Cao, Xiaotao Li, Shengping Zhang^*, Chuangui Wang^*, Loss of KLF14 triggers centrosome amplification and tumorigenesis. Nature Communications (IF:12.353), 2015 Oct 6; 6:8450 ncomms9450.

4. Shuxian Dong^#, Caifeng Jia^#, Shengping Zhang^#, Guangjian Fan, Yubing Li, Peipei Shan, Lianhui Sun, Wenzhen Xiao, Lei Li, Yi Zheng, Jinqin Liu, Haibing Wei, Chen Hu, Wen Zhang, Y. Eugene Chin, Qiwei Zhai, Qiao Li, Jian Liu, Fuli Jia, Qianxing Mo, Dean P. Edwards, Shixia Huang, Lawrence Chan, Bert W. O’Malley, Xiaotao Li*, Chuangui Wang*, The REGγ proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metabolism (IF:20.565), 2013 Sep 3;18(3):380-91.

5. Jiang Liu^#, Ying Wang^#, Lei Li, Li Zhou, Haibin Wei, Qingxia Zhou, Jian Liu, Weicang Wang, Lei Ji, Peipei Shan, Yan Wang, Yuanyuan Yang, Sung Yun Jung, Pei Zhang, Chuangui Wang, Weiwen Long, Bianhong Zhang*, Xiaotao Li*, Site-specific Acetylation of the Proteasome Activator REGγ Directs Its Heptameric Structure and Functions. J Biol Chem (IF:4.010 ), 2013 Jun 7;288(23):16567-78.

6. Zhixia Zhou, Zhijuan Lin, Xin Pang, Peipei Shan, Jianxun Wang^*. MicroRNA regulation of Toll-like receptor signaling pathways in teleost fish. Fish Shellfish Immunol (IF:3.185), 2018. 75: p. 32-40

7. Zhixia Zhou^#, Zhijuan Lin^#,Yuqi He, Xin Pang, Yin Wang, Murugavel Ponnusamy, Xiang Ao, Peipei Shan, Muhammad Akram Tariq, Peifeng Li^*, and Jianxun Wang^*. The Long Noncoding RNA D63785 Regulates Chemotherapy Sensitivity in Human Gastric Cancer by Targeting miR-422a. Molecular Therapy - Nucleic Acids (IF:5.660), 2018. 12: p. 405-419.