卓越人才：曾焕玉

曾焕玉（Lynn Htet Htet Aung），女，博士，讲师

2014年6月毕业于广西医科大学，获内科学博士学位。同年12月进入美国芝加哥伊利诺伊大学医学院从事博士后研究。2017年7月进入威斯尼斯人8188cc工作，入选威斯尼斯人8188cc青年卓越人才计划，现任分子遗传中心主任。目前主持国家自然科学海外青年基金一项，山东省自然科学基金一项，共发表SCI论文46篇，其中以第一作者或共同通讯作者身份发表13篇。

研究方向

利用高通量测序，生物信息学，细胞生物学方法研究衰老及心脑血管疾病的机理机制。

1. 探索易老化的表观遗传因素

2. 探讨心血管代谢疾病的表观遗传危险因素

3. 心血管代谢疾病的表观遗传危险因素研究

4. 心脏线粒体动力学的分子机制研究

代表论文：(^#第一作者，^*通讯作者)

1. Lynn Htet Htet Aung#*, Yu-Zhen Li#, Hua Yu, Xiatian Chen, Zhongjie Yu, Jinning Gao and Peifeng Li*. Mitochondrial protein 18 is a positive apoptotic regulator in cardiomyocytes under oxidative stress. Clini Sci. 2019;133:1067–1084.

2. Lynn Htet Htet Aung^#, Ruibei Li, Bellur S. Prabhakar, Peifeng Li*. Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission. J Cell Mol Med. 2017; 21(12):3394-3404.

3. Lynn Htet Htet Aung^#, Ruibei Li, Ajay V. Maker, Bellur S. Prabhakar, Peifeng Li*. Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis. Oncotarget. 8(34):56582-56597.

4. Jing Wang^#, Lynn Htet Htet Aung^#, Bellur S. Prabhakar, Peifeng Li*. 2016 The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission. J Cell Mol Med. 2016; 20(12):2278-2288.

5. Jincheng Li^#, Lynn Htet Htet Aung^#, Bo Long^#, Danian Qin*, Shejuan An, Peifeng Li*. 2015 miR-23a binds to p53 and enhances its association with miR-128 promoter. Sci Rep. 5:16422.

6. Aung LH^#, Yin RX*, Wu DF, Wang W, Liu CW, Pan SL. 2014 Association of the Variants in the BUD13-ZNF259 Genes and the Risk of Hyperlipidemia. J Cell Mol Med. doi: 10.1111/jcmm.12291. 

7. Aung LH^#, Yin RX*, Wu DF, Wang W, Wu JZ, Liu CW. 2014 Sex-specific Association of the Zinc Finger Protein 259 rs2075290 Polymorphism and Serum Lipid Levels. Int J Med Sci. 11(5):471-478. 

8. Aung LH^#, Yin RX*, Wu DF, Cao XL, Hu XJ, Miao L. 2013 Proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism interacts with alcohol consumption to modulate serum lipid levels. Int J Med Sci 10:124-132. 

9. Aung LH^#, Yin RX*, Wu DF, Yan TT, Li Q, Wu JZ, Lin WX, Liu CW, Pan SL. 2013 Association  of the apolipoprotein M gene polymorphisms and serum lipid levels. Mol Biol Rep. 40:1843-1853. 

10. Aung LH^#, Yin RX*, Miao L, Hu XJ, Yan TT, Cao XL, Wu DF, Li Q, Pan SL, Wu JZ. 2011 The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis. 10:5. 

11. Aung LH^#, Yin RX*, Wu DF, Li Q, Yan TT, Wang YM, Li H, Wei DX, Shi YL, Yang DZ. 2011 Association of the TRIB1 tribbles homolog 1 gene rs17321515 A>G polymorphism and serum lipid levels in the Mulao and Han populations. Lipids Health Dis. 10:230.