卓越人才：高岩岩

高岩岩，女，博士，讲师。

2014年7月毕业于中国科学院生物物理研究所生物化学与分子生物学专业，获博士学位。2015年至2017年在江苏省原子医学研究所研究部任助理研究员，2017年9月以威斯尼斯人8188cc青年卓越人才层次进入转化医学院工作。主持国家自然科学基金青年项目一项，江苏省自然科学基金一项，中国博士后基金特别资助一项，中国博士后基金面上项目一项，青岛市应用基础研究计划一项。在Nature Structural & Molecular Biology，Biochim Biophys Acta，FEBS Journal等杂志发表多篇SCI论文。

研究方向：心血管疾病及肿瘤线粒体蛋白质翻译调控及线粒体稳态研究。

代表论文：（#第一作者，*通讯作者）

1. Yanyan Gao^#*, Fang Yang^# , Xiu-An Yang^# , Li Zhang, Huixin Yu, Xian Cheng, Shichen Xu, Jie Pan, Kun Wang, Peifeng Li*. Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer. The FEBS Journal, 2019, 286(7) : 1420-1436.  

2.Yanyan Gao^#, Xiufeng Bai^#, Dejiu Zhang, Chunsheng Han, Jing Yuan, Wenbin Liu, Xintao Cao, Zilei Chen, Fugen Shangguan, Zhenyuan Zhu, Fei Gao and Yan Qin*. Mammalian elongation factor 4 regulates mitochondrial translation essential for spermatogenesis. Nature Structural & Molecular Biology 2016 (23):441–449.

3. Fang Yang ^#, Yanyan Gao ^#, Zhikai Li, Luming Chen, Zhiping Xia, Tao Xu, Yan Qin *. Mitochondrial EF4 links respiratory dysfunction and cytoplasmic translation in Caenorhabditis elegans. Biochim Biophys Acta. 2014 Oct;1837(10):1674-83.

4. Xian Cheng^#,Yanyan Gao, Xin Yao, Huixin Yu, Jiandong Bao, Haixia Guan,Yang Sun,Li Zhang*. Punicalagin induces apoptosis-independent autophagic cell death in human papillary thyroid carcinoma BCPAP cells.RSC Adv. 2016(6): 68485–68493.

5. Li Zhang^#, Xian Cheng^#, Yanyan Gao, Jie Zheng, Qiang Xu, Yang Sun, Haixia Guan, Huixin Yu* and Zhen Sun*. Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells. Food Funct. 2015 Nov;6(11):3464-72.

6. Li Zhang, Xian Cheng, Yanyan Gao, Jiandong Bao, Haixia Guan, Rongrong Lu, Huixin Yu*, Qiang Xu, Yang Sun*. Induction of ROS-independent DNA damage by curcumin leads to G2/M cell cycle arrest and apoptosis in human papillary thyroid carcinoma BCPAP cells. Food Funct. 2016 Jan 20;7(1):315-25.

7. Li Zhang, Xian Cheng, Yanyan Gao, Chiyu Zhang, Jiandong Bao, Haixia Guan, Huixin Yu, Rongrong Lu*, Qiang Xu*, Yang Sun *. Curcumin inhibits metastasis in human papillary thyroid carcinoma BCPAP cells via down-regulation of the TGF-β/Smad2/3 signaling pathway. Exp Cell Res. 2016 Jan 27;341:157-165.