周志侠,女,博士,讲师
2012年6月于山东大学获得博士学位;2012年7月至2014年12月在中国科学院海洋研究所从事博士后研究;2015年1月进入威斯尼斯人8188cc工作,2015年入选威斯尼斯人8188cc卓越人才计划第一层次。主要从事天然免疫识别与调节、肿瘤免疫调节与治疗、非编码RNA与肿瘤形成等方面的研究。以第一作者在Cancer Letters、Molecular Cancer Therapeutics等期刊上发表论文20余篇。主持包括国家自然科学基金在内的5项基金。
研究方向:
1. TLRs激动剂介导的机体免疫调节
2.肝癌的免疫调节与治疗
3.非编码RNA在肿瘤发生发展中的作用
联系方式:zhou_zhixia@126.com
代表论文:
(1) Zhixia Zhou#,Zhijuan Lin#, Yuqi He,Xin Pang, Yin Wang, Murugavel Ponnusamy, Xiang Ao, Peipei Shan,Muhammad AkramTariq, Peifeng Li*, Jianxun Wang*. The Long noncoding RNA D63785 regulates chemotherapy sensitivity in human gastric cancer by targeting miR-422a, Molecular Therapy-Nucleic Acids, 2018, 12:405-419.
(2) Zhijuan Lin#, Zhixia Zhou#, Hang Guo, Yuqi He, Xin Pan, Xumei Zhang, Ying Liu, Xiang Ao,Peifeng Li*, Jianxun Wang*. Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4,Cell Death & Disease, 2018,9(6):607
(3) Zhixia Zhou#, Chengyu Yang#, Fuyan Lv, Wenmiao Liu,Shengli Yan,Hongwei Zang, Miaomiao Li, Fang Wang, Yucui Zang*, Shiguo Liu*. Novel THRB mutation analysis in congenital hypothyroidism with thyroid dysgenesis, Journal of Cellular Biochemistry, 2018,119(11):9474-9482
(4) Zhixia Zhou, Xin Yu, Jian Zhang, Zhigang Tian*, Cai Zhang*.TLR7/8 agonists promote NK–DC cross-talk to enhance NK cellanti-tumor effects in hepatocellular carcinoma, Cancer Letters,2015, 369(2):298-306.
(5) Zhixia Zhou, Cai Zhang*, Chengfeng Xia, Wenlan Chen, Huawei Zhu, Pingping Shang, Fang Ma, Peng George Wang, Jian Zhang,Wenfang Xu, Zhigang Tian*. Enhanced antitumor effects by chemical modified IGb3 analogues,Molecular Cancer Therapeutics, 2011, 10(8):1375-1384.